Transplanted Bone Marrow-derived Cell Migration into Periodontal Tissues and Cell Differentiation

• Muraoka Rina

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Tsujigiwa Hidetsugu

  Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Nakano Keisuke

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Katase Naoki

  Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Tamamura Ryo

  Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Tomida Mihoko

  Orofacial Neuroscience Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Okafuji Norimasa

  Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Nagatsuka Hitoshi

  Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kawakami Toshiyuki

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

Bibliographic Information

Other Title

• 移植骨髄由来細胞の歯周組織への移動と細胞分化

Abstract

We examined the transplanted bone marrow-derived cell migration into periodontal tissues. Bone marrow cells from green fluorescent protein (GFP) transgenic mice were transplanted. The immunohistochemistry (IHC) revealed that GFP-positive cells were detected in the periodontal tissues. The GFP-positive cells histopathologically differentiated into some cell types. The fluorescence IHC and TRAP staining techniques demonstrated these cells were detected as osteoclasts and macrophages. Furthermore, GFP-positive cells gathered adjacent blood vessels. The data suggest that GFP-positive bone marrow-derived cell migrate into periodontal tissues and differentiate periodontal tissue component-cells.

Journal

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 20 (4), 301-306, 2011

  THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Keywords

• Bone marrow-derived cells
• Green fluorescent protein (GFP)
• Periodontal tissues
• Osteoclasts
• Macrophages
• Fibroblasts

Details

• CRID: 1390001204459697152
• NII Article ID: 130004848371
• NII Book ID: AA11074332
• DOI: 10.2485/jhtb.20.301
• COI: 1:CAS:528:DC%2BC38XhtVGhurvM
• ISSN: 1880828X
• ISSN: 13417649
• Web Site: https://mdu.repo.nii.ac.jp/records/2785
• Web Site: https://search.jamas.or.jp/link/ui/2012162424
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed