HSP70 Expression in the Mouse Dental Pulp after Immediate Teeth Separation

• Nakano Keisuke

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Saito Shinnosuke

  Oral Health Analysis Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Nabeyama Atsushi

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Oishi Shintaro

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine Department of Endodontics and Operative Dentistry, Matsumoto Dental University School of Dentistry

• Sato Masahiro

  Department of Endodontics and Operative Dentistry, Matsumoto Dental University School of Dentistry

• Yokoi Yukiko

  Department of Pediatric Dentistry, Matsumoto Dental University School of Dentistry

• Osuga Naoto

  Oral Health Analysis Unit, Matsumoto Dental University Graduate School of Oral Medicine Department of Pediatric Dentistry, Matsumoto Dental University School of Dentistry

• Okafuji Norimasa

  Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Kawakami Toshiyuki

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

Abstract

We examined the change of HSP70 expression in the mouse dental pulp which was exposed to experimental teeth separation by immunohistochemistry as a model for conservative dental treatment. Eight week-old 18 male ddY mice were used and a wedge was inserted between upper 1^st and 2^nd molars for 3 hours. In the experimental group, HSP70 expression increased in the dental pulp tissues. The expression was the greatest at 24 hours after which it gradually decreased to become similar to the level of the control group at 1 week. These results suggest that when immunohistochemical expression of HSP70 is used as an index, almost no severe damage occurs upon clinical application of a wedge insertion.

Journal

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 22 (1), 7-12, 2013

  THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Keywords

• HSP70
• Immediate teeth separation
• Dental Pulp
• Immunohistochemistry
• Mechanical stress

Details

• CRID: 1390282679435356672
• NII Article ID: 130004848413
• NII Book ID: AA11074332
• DOI: 10.2485/jhtb.22.7
• COI: 1:CAS:528:DC%2BC3sXms1Kgtrk%3D
• ISSN: 1880828X
• ISSN: 13417649
• NDL BIB ID: 024429368
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024429368
• Web Site: https://search.jamas.or.jp/link/ui/2014215528
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed