A study of recurrent giant odontogenic myxoma of the mandible with immunohistochemical examination of Notch

• Nakano Keisuke

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Chelvanayagam Peace

  Khmer-Soviet Friendship Hospital

• Born Kean

  Khmer-Soviet Friendship Hospital

• Siar Chong Huat

  Department of Oral Pathology, Oral Medicine & Periodontology, Faculty of Dentistry, University of Malaya

• Ng Kok Han

  Formerly Unit of Stomatology, Institute for Medical Research

• Nagatsuka Hitoshi

  Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Kawakami Toshiyuki

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

Abstract

Odontogenic myxoma, originating from the odontogenic ectomesenchyme, is an intraosseous benign neoplasm characterized by the presence of stellate and spindleshaped cells proliferating in an abundant myxoid or mucoid extracellular matrix. We experienced a giant case of this type of neoplasm. The patient was a 40-year-old Cambodian female with a presenting complaint of painless swelling of her gums since which had been present for 15 yaers. We examined the histopathological features and compared the mesenchymal tumoral tissue characteristics of this case with those of an ameloblastic fibroma with respect to Notch1 signaling. By immunohistochemical examination of Notch1 intracellular domain (NICD), we found that unlike the ameloblastic fibroma, NICD positive products were not observed in the current case of giant odontogenic myxoma. This negative staining result suggests that the ectomesenchymal tumoral proliferating cells of this neoplasm differ in their development stage from those of an ameloblastic fibroma.

Journal

• Oral Medicine & Pathology

  Oral Medicine & Pathology 12 (2), 53-56, 2008

  The Japanese Society of Oral Pathology

Keywords

• odontogenic myxoma
• giant tumor
• Notch
• cell differentiation

Details

• CRID: 1390282679447019520
• NII Article ID: 130004850521
• DOI: 10.3353/omp.12.53
• ISSN: 18821537
• ISSN: 13420984
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed