Heparanase and its related molecules in odontogenic tumors

• Nagatsuka Hitoshi

  Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Naoki Katase

  Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Pwint Han Phuu

  Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Orofacial Pain and Oral Medicine Center, Divisions of Diagnostic Sciences, School of Dentistry, University of South California

• Tsujigiwa Hidetsugu

  Department of Virology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Huat Siar Chong

  Department of Oral Pathology and Medicine, Faculty of Dentistry, University of Malaya

• Nakajima Motowo

  New Business and Transfer, Johnson & Johnson K.K.

• Naomoto Yoshio

  Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Tamamura Ryo

  Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

• Kawakami Toshiyuki

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Mehmet Gunduz

  Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

抄録

Heparan sulphate proteoglycans (HSPGs) constitute a group of ubiquitous macromolecules of cell surface and extracellular matrices (ECM). HS chains of HSPGs can bind numerous molecules including growth factors, cytokines and chemokines. Thus the degradation of HS chains by endoglycosidases will affect profoundly cell function. Heparanase is a mammalian endo-β-glucuronidase enzyme capable of selectively degrading HS chains. Aside from the enzymatic functions, heparanase is preferentially expressed by human tumors, and its over-expression in tumor cells provides invasive phenotype. We previously reported that heparanase expression and the HS-bound molecules are important for odontogenesis and development of odontogenic tumors. It can be concluded that the growth and progression of benign and malignant odontogenic tumors are related to the deranged immunoexpression and localization of HS and heparanase molecules and that heparanase may be responsible for growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors.

収録刊行物

• Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ

  Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ 13 (3), 81-89, 2009

  特定非営利活動法人 日本臨床口腔病理学会

キーワード

• bone morphogenetic protein (BMP)
• heparan sulphate (HS)
• heparanase
• immunohistochemistry
• odontogenic tumors

詳細情報

• CRID: 1390001204470959872
• NII論文ID: 130004850527
• DOI: 10.3353/omp.13.81
• ISSN: 18821537
• ISSN: 13420984
• Web Site: https://search.jamas.or.jp/link/ui/2010027096
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可