Effects of PUFA, Especially Arachidonic Acid on the Aged Brain Function and It’s Mechanisms

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  • SAKAKIBARA Manabu
    Tokai University, School of High-Technology for Human Welfare, Department of Biological Science and Technology

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  • アラキドン酸を中心とする高度不飽和脂肪酸が加齢脳に及ぼす効果とそのメカニズム
  • アラキドンサン オ チュウシン ト スル コウド フホウワ シボウサン ガ カレイノウ ニ オヨボス コウカ ト ソノ メカニズム

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Abstract

The nervous system, in contrast to other tissues, is enriched in the polyunsaturated fatty acid (PUFA), arachidonic acid (ARA, 20:4 ω-6) and docosahexaenoic acid (DHA, 22:6, ω-3). Despite their abundance in the nervous system, ARA and DHA cannot be synthesized de novo by mammals, must be obtained from dietary sources and transported to the brain, thus they are termed “essential fatty acids”. It is generally accepted that PUFA is particularly important for visual system maturation and brain development during infancy. Recent findings suggest that PUFA also plays a key role in maintaining cognitive function in elderly people and that supplementing the diet with PUFA improves some neurologic disorders. The effects of PUFA on cognitive function revealed by the results of animal experiments from the view point of behavior, electrophysiology, opto-physiology, membrane-biophysics, immunohistochemistry, and biochemistry are summarized in this review.

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  • Oleoscience

    Oleoscience 12 (7), 273-282, 2012

    Japan Oil Chemists' Society

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