A Case of Late Onset Myoclonic Epilepsy in Down Syndrome (LOMEDS)

• Ishibashi Hideaki

  Department of Neurosurgery, Asahikawa Medical University Department of Neurosurgery, Kaizuka Hospital

• Shigeto Hiroshi

  Department of Neurology, Graduate School of Medical Sciences, Kyushu University

• Onitsuka Toshiaki

  Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title

• Down症候群に合併した遅発性ミオクロニーてんかんの一例

Abstract

Myoclonic epilepsy is being increasingly recognized as a late onset complication in middle-aged or elderly patients with Down syndrome, in association with acute cognitive decline or dementia. We report a case of late onset myoclonic epilepsy in Down syndrome (LOMEDS) with acute cognitive decline, aged 45 year-olds. Although her intelligence condition remained poor with one to two-words sentences and difficult in following commands even after treatment, induction of levetiracetam and lamotorigin resulted in rapid, sustained seizure freedom and upgrading social activity with no adverse events. A combination of levetiracetam and lamotorigin appear to be effective for LOMEDS, and could be considered as first line agents for this special condition.

Journal

• Journal of the Japan Epilepsy Society

  Journal of the Japan Epilepsy Society 32 (3), 564-567, 2015

  JAPAN EPILEPSY SOCIETY

Keywords

• Down syndrome
• epilepsy
• elderly
• dementia

Details

• CRID: 1390001204517304704
• NII Article ID: 130004856094
• DOI: 10.3805/jjes.32.564
• ISSN: 13475509
• ISSN: 09120890
• Web Site: https://search.jamas.or.jp/link/ui/2015182940
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed