Rapid Synthesis of 62Zn-Labeled <i>S</i>-Glycosylated Porphyrin as Positron Emission Tomography Tracers for In Vivo PET Imaging

• Masato Tamura

  Faculty of Medicine, University of Tsukuba

• Hirofumi Matsui

  Faculty of Medicine, University of Tsukuba

• Shiho Hirohara

  Department of Chemical and Biological Engineering, Ube National Collage of Technology

• Kiyomi Kakiuchi

  Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST)

• Masao Tanihara

  Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST)

• Naruto Takahashi

  Graduate School of Science, Osaka University

• Kozi Nakai

  Graduate School of Science, Osaka University

• Yasukazu Kanai

  Department of Molecular Imaging in Medicine, Graduate School of Medicine, Osaka University

• Hiroshi Watabe

  Department of Molecular Imaging in Medicine, Graduate School of Medicine, Osaka University

• Jun Hatazawa

  Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University

抄録

Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin® and bisglycosylated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrins (H2Glccis-2 and H2Glctrans-2), which can be easily synthesized and have a half-life of 9 h. 62Zn-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.

収録刊行物

• Chemistry Letters

  Chemistry Letters 43 (6), 778-780, 2014-02-21

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360565169058925952
• NII論文ID: 130004868163
• DOI: 10.1246/cl.140056
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/43/6/778/55641876/cl.140056.pdf
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