Change in Overhauser Effect-enhanced MRI Signal in Response to uPA Highly Expressing in Tumor

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Author(s)

    • Niidome Takuro
    • Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology, Kumamoto University
    • Yamasaki Toshihide
    • Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University
    • Yamada Ken-ichi
    • Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University
    • Mori Takeshi
    • Department of Applied Chemistry, Faculty of Engineering, Kyushu University|Center for Future Chemistry, Kyushu University
    • Utsumi Hideo
    • Innovation Center for Medical Redox Navigation, Kyushu University
    • Katayama Yoshiki
    • Department of Applied Chemistry, Faculty of Engineering, Kyushu University|Center for Future Chemistry, Kyushu University|Innovation Center for Medical Redox Navigation, Kyushu University

Abstract

Dendritic poly(<small>L</small>-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

Journal

  • Chemistry Letters

    Chemistry Letters 43(7), 999-1001, 2014

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130004868241
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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