Change in Overhauser Effect-enhanced MRI Signal in Response to uPA Highly Expressing in Tumor
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Dendritic poly(<small>L</small>-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.
- Chemistry Letters
Chemistry Letters 43(7), 999-1001, 2014
The Chemical Society of Japan