Intracellular Delivery of Anionic <i>meso</i>-Tetraarylporphyrin–Per-<i>O</i>-methylated β-Cyclodextrin Supramolecular Complexes by an Oligoarginine Carrier Peptide

DOI PDF 被引用文献4件 参考文献13件
  • Hiroaki Kitagishi
    Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
  • Keiko Minami
    Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University
  • Koji Kano
    Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University

抄録

<jats:title>Abstract</jats:title> <jats:p>A 1:2 inclusion complex composed of 5-[4-(tetraglutaminylglutaramido)phenyl]-10,15,20-tris(4-sulfonatophenyl)porphyrin and per-O-methylated β-cyclodextrin interacted electrostatically with a dodecaarginine in aqueous solution. Such a ternary complex dispersed in a serum-containing culture medium was efficiently taken up by HeLa cells. This cellular uptake was achieved owing to the interaction between the tetraglutamate chain of the porphyrin and dodecaarginine carrier peptide.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 43 (7), 1095-1097, 2014-04-25

    Oxford University Press (OUP)

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