Suppression of Nonspecific Protein–Nanodiamond Adsorption Enabling Specific Targeting of Nanodiamonds to Biomolecules of Interest
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- Shingo Sotoma
- Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
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- Ryuji Igarashi
- Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
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- Jun Iimura
- Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
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- Yuta Kumiya
- Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
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- Hidehito Tochio
- Department of Biophysics, Graduate School of Science, Kyoto University
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- Yoshie Harada
- Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University
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- Masahiro Shirakawa
- Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
抄録
<jats:title>Abstract</jats:title> <jats:p>Applications of nanodiamonds (NDs) to bioimaging are restricted because of the nonspecific adsorption of biomolecules on the surface of NDs. Here, we show that hyperbranched polyglycerol-modified nanodiamond realizes both excellent dispersibility and marked suppression of nonspecific adsorption to proteins. Moreover, selective targeting to the proteins of interest, and the measurement of optically detected magnetic resonance from this nanodiamond on living cells are demonstrated.</jats:p>
収録刊行物
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- Chemistry Letters
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Chemistry Letters 44 (3), 354-356, 2014-12-19
Oxford University Press (OUP)
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キーワード
詳細情報 詳細情報について
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- CRID
- 1360283694082335872
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- NII論文ID
- 130004868380
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- ISSN
- 13480715
- 03667022
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