Suppression of Nonspecific Protein–Nanodiamond Adsorption Enabling Specific Targeting of Nanodiamonds to Biomolecules of Interest

• Shingo Sotoma

  Department of Molecular Engineering, Graduate School of Engineering, Kyoto University

• Ryuji Igarashi

  Department of Molecular Engineering, Graduate School of Engineering, Kyoto University

• Jun Iimura

  Department of Molecular Engineering, Graduate School of Engineering, Kyoto University

• Yuta Kumiya

  Department of Molecular Engineering, Graduate School of Engineering, Kyoto University

• Hidehito Tochio

  Department of Biophysics, Graduate School of Science, Kyoto University

• Yoshie Harada

  Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University

• Masahiro Shirakawa

  Department of Molecular Engineering, Graduate School of Engineering, Kyoto University

Abstract

Applications of nanodiamonds (NDs) to bioimaging are restricted because of the nonspecific adsorption of biomolecules on the surface of NDs. Here, we show that hyperbranched polyglycerol-modified nanodiamond realizes both excellent dispersibility and marked suppression of nonspecific adsorption to proteins. Moreover, selective targeting to the proteins of interest, and the measurement of optically detected magnetic resonance from this nanodiamond on living cells are demonstrated.

Journal

• Chemistry Letters

  Chemistry Letters 44 (3), 354-356, 2014-12-19

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360283694082335872
• NII Article ID: 130004868380
• DOI: 10.1246/cl.141036
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/44/3/354/55643860/cl.141036.pdf
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