Stem Cells in Regenerative Medicine

• Sykova Eva

  Department of Neuroscience, Institute of Experimental Medicine, Academy of Science of the Czech Republic Department of Neuroscience, 2nd Faculty of Medicine, Charles University

• Forostyak Serhiy

  Department of Neuroscience, Institute of Experimental Medicine, Academy of Science of the Czech Republic

抄録

Background: A number of cardiovascular, neurological, musculoskeletal and other diseases have a limited capacity for repair and only a modest progress has been made in treatment of brain diseases. The discovery of stem cells has opened new possibilities for the treatment of these maladies, and cell therapy now stands at the cutting-edge of modern regenerative medicine and tissue engineering. Experimental data and the first clinical trials employing stem cells have shown their broad therapeutic potential and have brought hope to patients suffering from devastating pathologies of different organs and systems.<br>Aims: Here, we briefly review the main achievements and trends in cell-based therapy, with an emphasis on the main types of stem cells: embryonic, mesenchymal stromal and induced pluripotent cells. <br>Discussion: Many questions regarding the application of stem cells remain unanswered, particularly tumorigenicity, immune rejection and danger of gene manipulation. Currently, only MSC seems to be safe and might be considered to be a leading candidate for human application to treat pathologies that affect the cardiovascular, neurological and musculoskeletal systems.

収録刊行物

• レーザーセラピー

  レーザーセラピー 22 (2), 87-92, 2013

  国際光治療学会

キーワード

• Stem Cells
• Embryonic Stem Cells
• Mesenchymal Stromal Cells
• Induced Pluripotent Stem Cells
• Clinical Trials
• PACS: 87.19.L-; 87.19.LW

詳細情報

• CRID: 1390001204634121216
• NII論文ID: 130004872590
• DOI: 10.5978/islsm.13-re-01
• ISSN: 18847269
• ISSN: 08985901
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可