Expression of Pendrin Periostin in Allergic Rhinitis Chronic Rhinosinusitis
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- Ishida Akihiro
- Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
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- Ohta Nobuo
- Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
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- Suzuki Yusuke
- Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
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- Kakehata Seiji
- Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University
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- Okubo Kimihiro
- Department of Otolaryngology, Nippon Medical School
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- Ikeda Hiroki
- Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center
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- Shiraishi Hiroshi
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Faculty of Medicine, Saga Medical School
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- Izuhara Kenji
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Faculty of Medicine, Saga Medical School
書誌事項
- タイトル別名
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- Expression of Pendrin and Periostin in Allergic Rhinitis and Chronic Rhinosinusitis
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抄録
Background: Pendrin and periostin are newly identified mediators of the inflammatory process. The expression of these proteins in human sinonasal tissue and their roles in allergic rhinitis and chronic rhinosinusitis remain to be elucidated. This study investigated the expression of pendrin and periostin in sinonasal tissue of patients with allergic rhinitis, chronic rhinosinusitis, and aspirin-induced asthma. Prospective control study conducted at Yamagata University, Japan.<br> Methods: Surgical samples were investigated by means of real-time reverse transcription-polymerase chain reaction to evaluate the expression of pendrin and periostin mRNA. The presence and location of pendrin and periostin were determined by immunohistochemistry and Western blotting.<br> Results: Pendrin and periostin production was significantly higher in patients with nasal disorders than in controls. Further significant increases in periostin expression were noted in patients with chronic rhinosinusitis with nasal polyps and in those with aspirin-induced asthma. Immunohistochemistry revealed positive staining for pendrin in epithelial cells and submucosal glands and for periostin in the basement membrane in all three disorders, and additionally for periostin in nasal polyp tissue in chronic rhinosinusitis and aspirin-induced asthma.<br> Conclusions: Production of pendrin and periostin is upregulated in allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma. These findings suggest that pendrin can induce mucus production and that periostin can induce tissue fibrosis and remodeling in the nasal mucosa. Therefore, these mediators may be therapeutic target candidates for allergic rhinitis, chronic rhinosinusitis with nasal polyps, and aspirin-induced asthma.<br>
収録刊行物
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- Allergology International
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Allergology International 61 (4), 589-595, 2012
一般社団法人日本アレルギー学会
