Oral Mite Anaphylaxis Caused by Mite-Contaminated Okonomiyaki/ Pancake-Mix in Japan: 8 Case Reports and a Review of 28 Reported Cases
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- Takahashi Kentaro
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital Department of Allergy and Clinical Immunology, Chiba University Hospital
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- Taniguchi Masami
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Fukutomi Yuma
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Sekiya Kiyoshi
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Watai Kentaro
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Mitsui Chihiro
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Tanimoto Hidenori
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Oshikata Chiyako
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Tsuburai Takahiro
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Tsurikisawa Naomi
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Minoguchi Kenji
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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- Nakajima Hiroshi
- Department of Allergy and Clinical Immunology, Chiba University Hospital
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- Akiyama Kazuo
- Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
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抄録
Background: Anaphylaxis after the ingestion of foods contaminated with mites has recently been recognized. Case series and case reports thus far have shown that mite-contaminated wheat flour is the major cause of oral mite anaphylaxis. However, we have found 8 cases of oral mite anaphylaxis which were caused by mite-contaminated okonomiyaki-mix, a savory Japanese style pancake mix, in our hospital.<br> Methods: In addition to our 8 cases, the databases of MEDLINE and ICHUSHI were systematically searched for patients with oral mite anaphylaxis in Japan.<br> Results: Thirty-six patients including our 8 cases with oral mite anaphylaxis were identified. Thirty-four out of 36 cases (94%) ingested okonomiyaki or takoyaki, prepared at home using okonomiyaki-mix or takoyaki-mix which was previously opened and stored for months at ambient temperature. Microscopic examination of culprit mixes of 16 cases including our 1 case revealed contamination of mites such as Dermatophagoides farina (Der f) (5 cases), Tyrophagus putrescentiae (Tyr p) (4 cases), and Dermatophagoides pteronyssinus (Der p) (3 cases). The specific IgE to each mite is generally upregulated in these patients. Especially, the titers of specific IgE to Der p and Der f were more than class 2 in all cases.<br> Conclusions: Mite-contaminated flavored flour is the major cause of oral mite anaphylaxis in Japan.<br>
収録刊行物
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- Allergology International
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Allergology International 63 (1), 51-56, 2014
一般社団法人日本アレルギー学会