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- Liu Min
- Department of Biochemistry, Juntendo University School of Medicine Department of Respiratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
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- Yokomizo Takehiko
- Department of Biochemistry, Juntendo University School of Medicine
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抄録
Leukotrienes (LTs), both LTB4 and the cysteinyl LTs (CysLTs) LTC4, LTD4 and LTE4, are implicated in a wide variety of inflammatory disorders. These lipid mediators are generated from arachidonic acid via multistep enzymatic reactions through which arachidonic acid is liberated from membrane phospholipids through the action of phospholipase A2. LTB4 and CysLTs exert their biological effects by binding to cognate receptors, which belong to the G protein-coupled receptor superfamily. LTB4 is widely considered to be a potent chemoattractant for most subsets of leukocytes, whereas CysLTs are potent bronchoconstrictors that have effects on airway remodeling. LTs play a central role in the pathogenesis of asthma and many other inflammatory diseases. This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers.
収録刊行物
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- Allergology International
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Allergology International 64 (1), 17-26, 2015
一般社団法人日本アレルギー学会
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詳細情報
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- CRID
- 1390282679609087872
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- NII論文ID
- 130004873117
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可