Prostanoids in allergy

• Honda Tetsuya

  Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine Department of Dermatology, Kyoto University Graduate School of Medicine

• Kabashima Kenji

  Department of Dermatology, Kyoto University Graduate School of Medicine

Abstract

Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. They induce a range of actions mediated through their respective receptors expressed on target cells. It has been demonstrated that each prostanoid receptor has multiple functions and that the effect of receptor stimulation can vary depending on context; this sometimes results in opposing effects, such as simultaneous excitatory and inhibitory outcomes. The balance between the production of each prostanoid and the expression of its receptors has been shown to be important for maintaining homeostasis but also involved in the development of various pathological conditions such as allergy. Here, we review the recent findings on the roles of prostanoids in allergy, especially focusing on atopic dermatitis and asthma.

Journal

• Allergology International

  Allergology International 64 (1), 11-16, 2015

  Japanese Society of Allergology

Keywords

• Atopic dermatitis
• Contact dermatitis
• Prostaglandin
• Prostanoid
• Thromboxane

Details

• CRID: 1390282679608523264
• NII Article ID: 130004873121
• DOI: 10.1016/j.alit.2014.08.002
• ISSN: 14401592
• ISSN: 13238930
• HANDLE: 2433/216498
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000094?httpAccept=text/plain
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000094?httpAccept=text/xml
• Web Site: https://search.jamas.or.jp/link/ui/2016025876
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed