IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test

• Minami Takafumi

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Fukutomi Yuma

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Lidholm Jonas

  Thermo Fisher Scientific

• Yasueda Hiroshi

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Saito Akemi

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Sekiya Kiyoshi

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Tsuburai Takahiro

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Maeda Yuji

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Mori Akio

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Taniguchi Masami

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Hasegawa Maki

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

• Akiyama Kazuo

  Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

抄録

Background: Limited information is available regarding the clinical usefulness of measuring the levels of IgE to allergen components from house dust mites (HDMs) in the diagnosis of genuine HDM allergy.<br>Methods: To evaluate the diagnostic usefulness of measuring levels of serum IgE antibodies (Abs) to allergen components from Dermatophagoides pteronyssinus (DP) as a predictor of immediate asthmatic response (IAR) to bronchoprovocation, we studied 55 DP-sensitized asthmatic patients who underwent a bronchoprovocation test using crude DP extract. The levels of IgE Abs to crude DP, nDer p 1, rDer p 2, and rDer p 10 in patients who showed IAR (n = 41) were compared with those in patients who showed no IAR (n = 14).<br>Results: While the frequencies of positivity for IgE Abs to nDer p 1 and rDer p 2 among the entire study population were 89 and 86%, respectively, all patients with IAR tested positive for both of them with high IgE concentrations. The areas under the receiver operating characteristic curves for IgE to nDer p 1 and rDer p 2 as predictors of IAR were 0.913 and 0.906, respectively. The specificity of IgE to nDer p 1 and rDer p 2 was higher than IgE to crude DP even at low cut-off points.<br>Conclusions: IgE to nDer p 1 and/or rDer p 2 was highly predictive of allergen-induced IAR. These findings validate the clinical usefulness of measuring the levels of IgE to nDer p 1 and rDer p 2 as a diagnostic tool for genuine HDM allergy.

収録刊行物

• Allergology International

  Allergology International 64 (1), 90-95, 2015

  一般社団法人日本アレルギー学会

キーワード

• <i>Bronchoprovocation</i>; <i>Component-resolved diagnostics</i>; <i>Dermatophagoides pteronyssinus</i>; House dust mite; Molecular-based allergy diagnostics

詳細情報

• CRID: 1390282679608549632
• NII論文ID: 130004873139
• DOI: 10.1016/j.alit.2014.08.004
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000124?httpAccept=text/plain
• Web Site: https://api.elsevier.com/content/article/PII:S1323893014000124?httpAccept=text/xml
• Web Site: https://search.jamas.or.jp/link/ui/2016025888
• 本文言語コード: en
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