IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test

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Author(s)

    • Minami Takafumi
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Taniguchi Masami
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Hasegawa Maki
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Akiyama Kazuo
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Fukutomi Yuma
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Yasueda Hiroshi
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Saito Akemi
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Sekiya Kiyoshi
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Tsuburai Takahiro
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Maeda Yuji
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital
    • Mori Akio
    • Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital

Abstract

<i>Background:</i> Limited information is available regarding the clinical usefulness of measuring the levels of IgE to allergen components from house dust mites (HDMs) in the diagnosis of genuine HDM allergy.<br><i>Methods:</i> To evaluate the diagnostic usefulness of measuring levels of serum IgE antibodies (Abs) to allergen components from <i>Dermatophagoides pteronyssinus</i> (DP) as a predictor of immediate asthmatic response (IAR) to bronchoprovocation, we studied 55 DP-sensitized asthmatic patients who underwent a bronchoprovocation test using crude DP extract. The levels of IgE Abs to crude DP, nDer p 1, rDer p 2, and rDer p 10 in patients who showed IAR (<i>n</i> = 41) were compared with those in patients who showed no IAR (<i>n</i> = 14).<br><i>Results:</i> While the frequencies of positivity for IgE Abs to nDer p 1 and rDer p 2 among the entire study population were 89 and 86%, respectively, all patients with IAR tested positive for both of them with high IgE concentrations. The areas under the receiver operating characteristic curves for IgE to nDer p 1 and rDer p 2 as predictors of IAR were 0.913 and 0.906, respectively. The specificity of IgE to nDer p 1 and rDer p 2 was higher than IgE to crude DP even at low cut-off points.<br><i>Conclusions:</i> IgE to nDer p 1 and/or rDer p 2 was highly predictive of allergen-induced IAR. These findings validate the clinical usefulness of measuring the levels of IgE to nDer p 1 and rDer p 2 as a diagnostic tool for genuine HDM allergy.

Journal

  • Allergology International

    Allergology International 64(1), 90-95, 2015

    Japanese Society of Allergology

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