Docosahexaenoic Acid-Induced Lipid Peroxidation and Urinary Excretion of Mercapturic Acid in Rats

• Sekine Seiji

  Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition Laboratory of Nourishment Biochemistry, Department of Applied Biology and Chemistry, Tokyo University of Agriculture

• Kubo Kazuhiro

  Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition Nursing Course, Narabunka Women's College, Incorporated Educational Institution, Nara Gakuen

• Tadokoro Tadahiro

  Laboratory of Nourishment Biochemistry, Department of Applied Biology and Chemistry, Tokyo University of Agriculture

• Saito Morio

  Division of Food Science, Incorporated Administrative Agency, National Institute of Health and Nutrition

抄録

We hypothesized a suppressive mechanism for dietary docosahexaenoic acid (DHA)-induced tissue lipid peroxidation in which the degradation products, especially aldehydic compounds, are conjugated with glutathione (GSH) through catalysis by glutathione S-transferases (GSTs), and then excreted into urine as mercapturic acids. Sprague-Dawley rats were fed a diet containing DHA (8.4 % of total energy) for 31 days. Lipid peroxides in the liver and kidney, liver GST and urinary excretion of mercapturic acid were measured. The lipid peroxide levels in the liver and kidney except the liver aldehydic compounds were higher, and the urinary excretion of mercapturic acid also tended to be higher in the DHA-fed rats although the activity of GST was not increased after DHA intake. We presume from our results that a proportion of the lipid peroxidation-derived aldehydic degradation products might be excreted into urine as mercapturic acid after intake of DHA, thus suppressing the accumulation of aldehydic products in tissues, particularly in the liver.<br>

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 39 (1), 40-45, 2006

  一般社団法人　日本酸化ストレス学会

キーワード

• Docosahexaenoic Acid
• Lipid peroxide
• Aldehyde
• Glutathione S-transferase
• Mercapturic acid

詳細情報

• CRID: 1390282679649670912
• NII論文ID: 130004879088
• DOI: 10.3164/jcbn.39.40
• COI: 1:CAS:528:DC%2BD28XpsFeisrk%3D
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2007054213
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
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