Sweet potato (Ipomoea batatas L.) leaves suppressed oxidation of low density lipoprotein (LDL) in vitro and in human subjects

DOI 10 Citations 27 References
  • Nagai Miu
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Tani Mariko
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Kishimoto Yoshimi
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Iizuka Maki
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Saita Emi
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Toyozaki Miku
    Institute of Environmental Science for Human Life, Ochanomizu University
  • Kamiya Tomoyasu
    Research and Development Division, Toyo Shinyaku Co., Ltd.
  • Ikeguchi Motoya
    Research and Development Division, Toyo Shinyaku Co., Ltd.
  • Kondo Kazuo
    Institute of Environmental Science for Human Life, Ochanomizu University

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Abstract

Sweet potato (Ipomoea batatas L.) leaves are consumed as vegetables around the world, especially in Southeast Asia. The aim of this study was to investigate the inhibitory effect of sweet potato leaves on low-density lipoprotein oxidation in vitro and in human subjects. We compared the antioxidant activity of 8 kinds of sweet potato leaves. Every sweet potato leaf had high radical scavenging activity and prolonged a lag time for starting low-density lipoprotein oxidation in vitro. We found that sweet potato leaves contained abundant polyphenol compounds and the radical scavenging activity and prolongation rate of lag time were highly correlated with total polyphenol content. We also confirmed that thiobarbituric acid reactive substances production was increased in endothelial cell-mediated low-density lipoprotein oxidation, which was decreased by treatment with sweet potato leaves. We further measured the low-density lipoprotein oxidizability in 13 healthy volunteers after their intake of 18 g of “Suioh”, raw sweet potato leaves. “Suioh” prolonged a lag time for starting low-density lipoprotein oxidation and decreased low-density lipoprotein mobility. These results suggest that sweet potato leaves have antioxidant activity leading to the suppression of low-density lipoprotein oxidation.<br>

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