Gingival vascular functions are altered in type 2 diabetes mellitus model and/or periodontitis model
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- Sugiyama Shuta
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Takahashi Shun-suke
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Tokutomi Fumi-aki
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Yoshida Ayaka
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Kobayashi Kyo
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Yoshino Fumihiko
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Wada-Takahashi Satoko
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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- Toyama Toshizo
- Department of Infection Control, Division of Microbiology, Kanagawa Dental College
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- Watanabe Kiyoko
- Department of Infection Control, Division of Microbiology, Kanagawa Dental College
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- Hamada Nobushiro
- Department of Infection Control, Division of Microbiology, Kanagawa Dental College
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- Todoki Kazuo
- Department of Dental Hygiene, Division of Oral Science & Pharmacology, Shonan Junior College
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- Lee Masaichi-Chang-il
- Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College
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The association of vascular reactivity between diabetes and periodontal disease has not been clarified. Gingival blood flow was measured by laser Doppler flowmetry for 31 weeks in Wistar rats, Wistar rats orally challenged with Porphyromonas gingivalis (Wistar rats + Porphyromonas gingivalis), Goto-Kakizaki rats, and Goto-Kakizaki rats orally challenged with Porphyromonas gingivalis (Goto-Kakizaki rats + Porphyromonas gingivalis). Effects of alveolar bone resorption on periodontal tissue was enhanced in Wistar rats + Porphyromonas gingivalis, and Goto-Kakizaki rats, with this effect being significantly enhanced by Goto-Kakizaki rats + Porphyromonas gingivalis. Using the L-band electron spin resonance technique, we succeeded in measuring oxidative stress as decay rate constant (K1 and K2) of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidin-1-yloxy in the oral and maxillofacial region of the animal models. The decay rate constant (K1) of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidin-1-yloxy was significantly greater in the oral and maxillofacial region of Goto-Kakizaki rats + Porphyromonas gingivalis compared to Wistar rats, Wistar rats + Porphyromonas gingivalis and Goto-Kakizaki rats groups. Gingival reactive hyperemia was attenuated by periodontal disease, and this effect was also remarkable in the diabetes mellitus model. Taken together, we found that vascular endothelial function was decreased in diabetes mellitus and/or periodontal disease animal models due to increasing oxidative stress in the gingival circulation.<br>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 51 (2), 108-113, 2012
一般社団法人 日本酸化ストレス学会