Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo
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- Yoshida Yasukazu
- Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)
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- Umeno Aya
- Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)
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- Shichiri Mototada
- Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST)
書誌事項
- タイトル別名
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- Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity <i>in vivo</i>
- Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity <italic>in vivo</italic>
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抄録
Recently, the biological roles of lipid peroxidation products have received a great deal of attention not only for elucidating pathological mechanisms but also for practical clinical applications as biomarkers. In the last 50 years, lipid peroxidation has been the subject of extensive studies from the viewpoints of mechanisms, dynamics, product analysis, involvement in diseases, inhibition, and biological signaling. Lipid hydroperoxides are formed as major primary products, but they are substrates for various enzymes and they also undergo various secondary reactions. During this decade, hydroxyoctadecadienoic acid from linoleates, F2-isoprostanes from arachidonates, and neuroprostanes from docosahexanoates have been proposed as biomarkers for evaluating oxidative stress in vivo and its related diseases. The implications of lipid peroxidation products in vivo will be briefly reviewed and their practical applications will be discussed.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 52 (1), 9-16, 2013
一般社団法人 日本酸化ストレス学会
