Immunomodulating compounds in Basidiomycetes

DOI PubMed 2 Citations
  • Mizuno Masashi
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • Nishitani Yosuke
    Team of Health Bioscience, Organization of Advanced Science and Technology, Kobe University

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Abstract

Mushrooms are distinguished as important food containing immunomodulating and anticancer agents. These compounds belong mostly to polysaccharides especially β-d-glucans. Among them, β-1,3-glucan with side chain β-1,6-glucose residues have more important roles in immunomodulating and antitumor activities. In this review, we have introduced polysaccharide mainly from Lentinula edodes and Agaricus blazei Murill with immunomodulating and antitumor activities. In addition, the mechanism of activation of immune response and signal cascade are also reviewed.

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