Polymorphisms in genes encoding antioxidant enzymes (<i>SOD2</i>, <i>CAT</i>, <i>GPx</i>, <i>TXNRD</i>, <i>SEPP1</i>, <i>SEP15</i> and <i>SELS</i>) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study
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Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (<i>SOD2</i>, <i>CAT</i>, <i>GPx</i>, <i>TXNRD</i>, <i>SEPP1</i>, <i>SEP15</i> and <i>SELS</i>) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (eGFR <60 ml/min/1.73 m<sup>2</sup>). When those with <i>CAT</i> C-262T <i>C/C</i> were defined as reference, those with <i>CAT</i> C-262T <i>C/T</i> demonstrated the OR for CKD of 0.67 (95% CI 0.43–1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of <i>T</i> allele (<i>p</i> = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of <i>T</i> allele of <i>CAT</i>, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
- Journal of Clinical Biochemistry and Nutrition
Journal of Clinical Biochemistry and Nutrition 53(1), 15-20, 2013
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