Polymorphisms in genes encoding antioxidant enzymes (<i>SOD2</i>, <i>CAT</i>, <i>GPx</i>, <i>TXNRD</i>, <i>SEPP1</i>, <i>SEP15</i> and <i>SELS</i>) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study
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- Hishida Asahi
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Okada Rieko
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Naito Mariko
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Morita Emi
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Wakai Kenji
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Hamajima Nobuyuki
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
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- Hosono Satoyo
- Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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- Nanri Hinako
- Department of Preventive Medicine, Faculty of Medicine, Saga University
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- Turin Tanvir Chowdhury
- Department of Health Science, Shiga University of Medical Science Department of Medicine, University of Calgary
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- Suzuki Sadao
- Department of Public Health, Nagoya City University Graduate School of Medical Sciences
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- Kuwabara Kazuyo
- Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University
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- Mikami Haruo
- Division of Epidemiology, Chiba Cancer Center Research Institute
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- Budhathoki Sanjeev
- Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences
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- Watanabe Isao
- Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine
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- Arisawa Kokichi
- Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Kubo Michiaki
- Center for Genomic Medicine, RIKEN
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- Tanaka Hideo
- Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Bibliographic Information
- Other Title
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- Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study
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Abstract
Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (eGFR <60 ml/min/1.73 m2). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43–1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 53 (1), 15-20, 2013
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