歯周病原性細菌に対する血清抗体価と年齢および局在菌数との関連

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タイトル別名
  • Relationship between Age and these Periodontopathic Bacterial Infections
  • Serum Antibodies to <I>Porphyromonas gingivalis</I> and <I>Fusobacterium nucleatum</I>
  • <I>Porphyromonas gingivalis</I>および<I>Fusobacterium nucleatum</I>について

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This study was carried out to clarify the relation between the age of individuals with or without gingivitis and their serum antibody levels against Porphyromonas gingivalis and Fusobacterium nucleatum and to examine the correlation between serum antibody titers to those microorganisms and their infection in the periodontal region. Forty patients with gingivitis and age matched control were used as subjects. Ten patients with adult periodontitis were also used as subjects. Blood samples were obtained from those individuals. Five groups were investigated from early childhood, school age, puberty, adult, adult periodontitis group. Serum IgG and IgM antibody levels against P. gingivalis 381, F. nucleatum ATCC25586 were determined using a micro-enzyme-linked immunosorbent assay. An increased serum antibody level against P. gingivalis in the school age group with gingivitis and a marked increase in the puberty group with gingivitis were found. The mean IgG level of 6970 EU in the puberty group with gingivitis was almost the same as that of the adult group with gingivitis and was approximately 1/20 that of the adult periodontitis group. The changes of the IgM antibody with age did not follow a pattern distinct from that for IgG. The mean level of IgM antibodies in the puberty group with gingivitis was significantly higher than that in the school age group with gingivitis and the adult groups with gingivitis and periodontitis. No significant difference in serum antibody level against F. nucleatum was noted among the puberty group with gingivitis, and the adult groups with gingivitis and periodontitis. A positive correlation was found between serum IgG antibody titers to P. gingivalis and the viable cell count of the microorganisms in the puberty group, and the adult group, while no correlation was found in the other groups. In all groups except the puberty group, no correlation was found between serum IgG antibody titers to F. nucleatum and viable cell cound numbers of the microorganism in the tested periodontal regions. In all groups, no correlation between serum IgM antibody titers against P. gingivalis and F. nucleatum and viable cell count numbers of those microorganisms in the tested periodontal regions was found.

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