プロブコール投与により血清コレステロールの著明な改善をみた家族性高コレステロール血症の一家系

J-STAGE
  • 阿部 隆三
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • 及川 真一
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • 佐野 隆一
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • 藤井 豊
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • 義江 和子
    The Third Department of Internal Medicine, Tohoku University School of Medicine
  • 後藤 由夫
    The Third Department of Internal Medicine, Tohoku University School of Medicine

書誌事項

タイトル別名
  • Marked Decrease of Serum LDL-cholesterol (LDL-C) Level after Treatment of Probucol in S. F. Family Who Showed Typical Familial Hypercholesterolemia

抄録

In the present study, effect of probucol (500mg×2, daily) on serum lipids and lipoproteins in S. F. family who showed typical familial hyper-cholesterolemia (FH) were investigated. The results were as follows:<br>1) The values of serum cholesterol (TC) before and after treatment of probucol were 348±14mg/dl and 220±12mg/dl, respectively. These data shows significant reduction of serum cholesterol after treatment of probucol. The percent of reduction of serum cholesterol was 36.4%. This value was significantly higher than the value (17%) in the other FH.<br>2) Though levels of LDL- and HDL-C were decreased after treatment of probucol, LDL-C level was markedly decrease in S. F family as compared with other FH. Reduction of HDL-C after treatment of probucol was not significant difference between in S. F family and other FH.<br>3) Total biliary lipids after treatment of probucol increased from 68.8μmol/ml to 141.9μmol/ml in a patient of S. F family. Level of bile acid increased after treatment of probucol, especially, in this case. On the other hand, the change of biliary lipids after treatment of probucol was not seen in other FH.<br>From these data, though mechanism of marked reduction of LDL-C in S. F family after treatment of probucol was still unclear, metabolism of cholesterol to synthesis of bile acid might have especially involved to marked reduction of serum LDL-C in S. F family.

収録刊行物

  • 動脈硬化

    動脈硬化 12 (4), 951-956, 1984

    Japan Atherosclerosis Society

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