血漿リポ蛋白代謝からみた高比重リポ蛋白 (HDL) の変動機構

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  • Study on Mechanism of Heparin-Induced VLDL-Catabolism in Variability of HDL-Cholesterol

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In order to elucidate the role of VLDL-catabolism in cholesterol content of HDL, we have determined the composition of plasma lipoprotein, before and 10 minutes after heparin infusion (10U/kg body weight) in men aged under 65 years old.<br>The twenty two subjects were divided into two groups according to triglyceride concentration in VLDL. Each lipoprotein fraction was separated by ultracentrifugation and then TCh (total cholesterol), FCh (free cholesterol), TG (triglyceride), and protein were determined by standard methods.<br>There was not significant change in plasma TCh after heparin infusion in spite of extreme decrease in VLDL-TG in all subjects. These results were indicated that total mass of TCh in plasma was not affected by enhance of VLDL-TG catabolism during 10 minutes induced by heparininfusion.<br>There was conflicting result which the degree of reduction of VLDL-TCh seen in VLDL-TG over 180mg/dl was not related to change in VLDL-TG. On the other hand, the degree of VLDL-TCh reduction in VLDL-TG under 180mg/dl was in proportion to decrease in VLDL-TG. Therefore, it was estimated that two behaivors existed in VLDL-catabolism as follow; (1) TG-hydrolysis in VLDL accompanied with TCh-transport into HDL, (2) Over-hydrolysis in VLDL-TG upon TCh-transport.<br>In eleven of 14 subjects with VLDL-TG under 180mg/dl, HDL-TCh increased (p<0.01) and this was not accompanied in TCh/protein ratio in HDL. In seven of 8 subjects with VLDL-TG over 180mg/dl, HDL-TCh decreased. These results were discussed in the context of the possible role of VLDL-catabolism in plasma lipoprotein metabolism.<br>We concluded that excess hydrolysis of TG in VLDL made it possible to increase in LDL-TCh rather than in HDL-TCh and to cause in cholesterol-rich VLDL with low content of cholesterol in HDL.

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