Novel Insights into Chk1 Regulation by Phosphorylation
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- Goto Hidemasa
- Division of Biochemistry, Aichi Cancer Center Research Institute Department of Cellular Oncology, Nagoya University Graduate School of Medicine
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- Kasahara Kousuke
- Division of Biochemistry, Aichi Cancer Center Research Institute Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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- Inagaki Masaki
- Division of Biochemistry, Aichi Cancer Center Research Institute Department of Cellular Oncology, Nagoya University Graduate School of Medicine
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Abstract
Checkpoint kinase 1 (Chk1) is a conserved protein kinase central to the cell-cycle checkpoint during DNA damage response (DDR). Until recently, ATR, a protein kinase activated in response to DNA damage or stalled replication, has been considered as the sole regulator of Chk1. Recent progress, however, has led to the identification of additional protein kinases involved in Chk1 phosphorylation, affecting the subcellular localization and binding partners of Chk1. In fact, spatio-temporal regulation of Chk1 is of critical importance not only in the DDR but also in normal cell-cycle progression. In due course, many potent inhibitors targeted to Chk1 have been developed as anticancer agents and some of these inhibitors are currently in clinical trials. In this review, we summarize the current knowledge of Chk1 regulation by phosphorylation.
Journal
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- Cell Structure and Function
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Cell Structure and Function 40 (1), 43-50, 2015
Japan Society for Cell Biology
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Details 詳細情報について
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- CRID
- 1390282679673264896
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- NII Article ID
- 130004885867
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- NII Book ID
- AA0060007X
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- ISSN
- 13473700
- 03867196
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- NDL BIB ID
- 027281665
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- PubMed
- 25748360
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed