弁付導管による肺動脈弁置換術の基礎的検討  [in Japanese] Pulmonary Valve Replacement with Valved Conduit  [in Japanese]

Access this Article

Author(s)

    • 篠田 麻子 SHINODA Asako
    • JASMINEどうぶつ循環器病センター|北里大学獣医畜産学部 Japan Animal Specialty Medical Institute Inc.|School of Veterinary Medicine, Kitasato University
    • 水越 崇博 MIZUKOSHI Takahiro
    • JASMINEどうぶつ循環器病センター|北里大学獣医畜産学部 Japan Animal Specialty Medical Institute Inc.|School of Veterinary Medicine, Kitasato University
    • 上地 正実 UECHI Masami
    • JASMINEどうぶつ循環器病センター|北里大学獣医畜産学部|日本大学生物資源科学部 Japan Animal Specialty Medical Institute Inc.|School of Veterinary Medicine, Kitasato University|College of Bioresource Sciences, Nihon University

Abstract

本研究の目的は,二尖弁の弁付導管を作成し肺動脈弁位に置換後の可動性,石灰化,抗血栓性を評価することである.供試犬は4頭の健常犬とした.弁付導管は,新鮮生体膜総鞘膜,デナコール処理済み生体膜あるいはePTFEパッチをトリミングして作製した.置換後の心臓超音波検査では弁の良好な可動性が確認できた.置換6カ月後の病理学的所見では血栓形成や顕著な石灰化は認められなかった.導管の内壁及び弁縫合周囲において線維芽細胞を含む内皮形成が認められた.今後,弁付導管置換後の機能についてより長期にわたり検討する必要が残るが,本研究の結果から,重度肺動脈狭窄症の犬に対する治療法として弁付導管による肺動脈弁置換術の有効性が示唆された.

The aim of this study was to evaluate the mobility, calcification, and anti-thrombotic properties of valved conduits for the surgical palliation of pulmonic stenosis in dogs. This study included four healthy dogs and valved conduits with two leaflets on the inner side. The three valved conduit types used in this study were autologous pericardium, denacol-treated bioprosthetic valve, and ePTFE. Postoperative echocardiography demonstrated the smooth movement of the leaflets in all valved conduit types. Histological examination of the specimens obtained six months after implantation did not show any thrombus or marked calcification. The surface of the conduit was covered by neointima, including fibroblasts, and was formed at the anastomosis of the valve. However, the long-term outcome of these implanted valved conduits requires further investigation. Nevertheless, these valved conduits may have potential applications for the surgical palliation of pulmonic stenosis in dogs.

Journal

  • Journal of the Japan Veterinary Medical Association

    Journal of the Japan Veterinary Medical Association 68(1), 49-54, 2015

    Japan Veterinary Medical Association

Codes

  • NII Article ID (NAID)
    130004888069
  • NII NACSIS-CAT ID (NCID)
    AN00191857
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0446-6454
  • NDL Article ID
    025998714
  • NDL Call No.
    Z18-352
  • Data Source
    NDL  J-STAGE  JASI 
Page Top