Multicenter Study of Modified Intravenous Olfactometry

DOI 3 References
  • Kobayashi Masayoshi
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine
  • Miwa Takaki
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University
  • Kurono Yuichi
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otolaryngology, Faculty of Medicine, Kagoshima University
  • Nibu Ken-ichi
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine
  • Matsune Shoji
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otolaryngology, Faculty of Medicine, Kagoshima University
  • Uchida Jun
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otorhinolaryngology, Showa University School of Medicine
  • Tsuzuki Kenzo
    The Committee of Investigation of Olfactory Function Tests of Japan Rhinologic Society Department of Otolaryngology, Hyogo College of Medicine
  • Kondo Kenji
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo
  • Shiga Hideaki
    Department of Otorhinolaryngology-Head and Neck Surgery, Kanazawa Medical University
  • Fujio Hisami
    Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine
  • Matsuwaki Yoshinori
    Department of Otorhinolaryngology, Jikei University School of Medicine
  • Honma Hirotomo
    Department of Otorhinolaryngology, Juntendo University Faculty of Medicine
  • Nakanishi Sayaka
    Department of Otorhinolaryngology - Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University
  • Mimura Hideya
    Department of Otolaryngology, School of Medicine, Fujita Health University
  • Ogawa Takao
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Shimizu Takeshi
    Department of Otorhinolaryngology, Shiga University of Medical Science
  • Takebayashi Hironori
    Department of Otolaryngology, Hyogo College of Medicine
  • Aiba Tsunemasa
    Department of Otorhinolaryngology, Osaka City General Hospital
  • Shojaku Hideo
    Department of Otolaryngology, Faculty of Medicine, University of Toyama

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Other Title
  • 静脈性嗅覚検査・希釈法の有用性に関する検討

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Abstract

A weak point of intravenous olfactometry using Alinamin® (prosultiamine) solution is that angialgia and fluctuation in the pattern of increase in intranasal smell perception are frequently observed during the test. A previous study reported that modified intravenous olfactometry using a 12-ml solution (6 × dilution by adding 10ml of saline to original 10mg [2ml] of prosultiamine solution) injected for 40 s is helpful for avoidance of angialgia and smell fluctuation. The present study was conducted to determine if the modified intravenous olfactometry is generally useful in many smell centers. A total of 143 normosmic subjects in 15 smell centers participated in this study. They were divided into two groups at random and the original or modified intravenous olfactometry was applied. There were no statistically significant differences between these two groups for latency or duration time of smell sensation, or frequency of the angialgia or smell fluctuation. In conclusion, the modified intravenous olfactometry does not exceed the original test in preventing angialgia or smell fluctuation.<br>

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