Methicillin-resistant <i>Staphylococcus aureus</i>-related Septic Pulmonary Embolism and Sacroiliitis Treated with Long-term Linezolid in a Patient with Adult-onset Still's Disease

  • Horai Yoshiro
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Izumikawa Koichi
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Oka Satoru
    Department of Nephrology, Nagasaki University Hospital, Japan
  • Nakashima Yoshikazu
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Suzuki Takahisa
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Nakajima Hideki
    Unit of Translational Medicine, Department of Clinical Neuroscience and Neurology, Nagasaki University, Graduate School of Biomedical Sciences, Japan
  • Kawashiri Shin-ya
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Iwamoto Naoki
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Ichinose Kunihiro
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Tamai Mami
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Nakamura Hideki
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Origuchi Tomoki
    Unit of Translational Medicine, Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Kohno Shigeru
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Kawakami Atsushi
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

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Other Title
  • Methicillin-resistant Staphylococcus aureus-related Septic Pulmonary Embolism and Sacroiliitis Treated with Long-term Linezolid in a Patient with Adult-onset Still's Disease

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Abstract

We herein report the case of a 21-year-old woman with refractory adult-onset Still's disease who developed central venous catheter-related methicillin-resistant Staphylococcus aureus sepsis during aggressive immunosuppressive therapy. She subsequently experienced septic pulmonary embolism (SPE) and sacroiliitis during treatment with intravenous vancomycin and was successfully treated with long-term oral linezolid therapy. This case suggests that the occurrence of methicillin-resistant Staphylococcus aureus infection in immunosuppressive patients can trigger severe clinical manifestations such as SPE and septic sacroiliitis and that linezolid is suitable for treating such conditions.<br>

Journal

  • Internal Medicine

    Internal Medicine 53 (9), 1023-1027, 2014

    The Japanese Society of Internal Medicine

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