Drug-induced Liver Injury with Serious Multiform Exudative Erythema following the Use of an Over-the-counter Medication Containing Ibuprofen
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- Watanabe Takao
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Abe Masanori
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Tada Fujimasa
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Aritomo Kanako
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Ochi Hironori
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Koizumi Yohei
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Tokumoto Yoshio
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Hirooka Masashi
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Kumagi Teru
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Ikeda Yoshio
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Matsuura Bunzo
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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- Hiasa Yoichi
- Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
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Abstract
A 36-year-old Japanese woman took over-the-counter (OTC) medication for headaches for 20 days. Subsequently, five days after discontinuing the medication, a skin rash developed over the patient's upper and lower limbs and face, in addition to a fever, brown urine and serious liver dysfunction. Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made. The patient's symptoms and liver function tests returned to normal following treatment with systemic steroids.<br>
Journal
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- Internal Medicine
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Internal Medicine 54 (4), 395-399, 2015
The Japanese Society of Internal Medicine
