Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats
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- SHINOZAKI Sachiyo
- Department of Neurophysiology, Akita University School of Medicine
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- SAITO Motoaki
- Division of Molecular Pharmacology, Tottori University School of Medicine
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- KAWATANI Masahito
- Department of Neurophysiology, Akita University School of Medicine
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抄録
Prostaglandins (PGs) are well known as one of the chemical mediators of inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs), PG synthesis inhibitors, are used for anti-nocoception and/or anti-inflammation. We examine the effect of loxoprofen, a NSAID, on micturiton in acetic acid-induced bladder inflammation of the rats. In cystometrogram study with saline infusion into the urinary bladder, loxoprofen did not alter the interval of bladder contraction (IC, 107% of the control). IC was shortened by acetic acid infusion (65% of the control) and loxoprofen prolonged the IC (162% of acetic acid infused period). This prolonged IC was approximately same as the control. Loxoprofen did not alter the threshold pressure and the maximal voiding pressure. These data suggest that PGE2 might not play a part of normal micturition and may play a part of the micturition reflex during acetic acid infusion. That is, loxoprofen might be useful for pathological hyperreflex of the micturition.
収録刊行物
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- Biomedical Research
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Biomedical Research 26 (1), 29-33, 2005
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