Oxygen plasma surface modification enhances immobilization of simvastatin acid

DOI PubMed 6 Citations 35 References
  • YOSHINARI Masao
    Department of Dental Materials Science, Oral Health Science Center, Tokyo Dental College
  • HAYAKAWA Tohru
    Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo
  • MATSUZAKA Kenichi
    Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College
  • INOUE Takashi
    Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College
  • ODA Yutaka
    Department of Dental Materials Science, Oral Health Science Center, Tokyo Dental College
  • SHIMONO Masaki
    Department of Pathology, Oral Health Science Center, Tokyo Dental College
  • IDE Takaharu
    Department of Oral Anatomy & Cell Biology, Graduate School of Dental Science, Kyushu University
  • TANAKA Teruo
    Department of Oral Anatomy & Cell Biology, Graduate School of Dental Science, Kyushu University

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Abstract

Simvastatin acid (SVA) has been reported to stimulate bone formation with increased expression of BMP-2. Therefore, immobilization of SVA onto dental implants is expected to promote osteogenesis at the bone tissue/implant interface. The aim of this study was to evaluate the immobilization behavior of SVA onto titanium (Ti), O2-plasma treated titanium (Ti + O2), thin-film coatings of hexamethyldisiloxane (HMDSO), and O2-plasma treated HMDSO (HMDSO + O2) by using the quartz crystal microbalance-dissipation (QCM-D) technique. HMDSO surfaces were activated by the introduction of an OH group and/or O2-functional groups by O2-plasma treatment. In contrast, titanium surfaces showed no appreciable compositional changes by O2-plasma treatment. The QCM-D technique enabled evaluation even at the adsorption behavior of a substance with a low molecular weight such as simvastatin. The largest amount of SVA was adsorbed on O2-plasma treated HMDSO surfaces compared to untreated titanium, HMDSO-coated titanium, and O2-plasma treated titanium. These findings suggested that the adsorption of SVA was enhanced on more hydrophilic surfaces concomitant with the presence of an OH group and/or O2-functional group resulting from the O2-plasma treatment, and that an organic film of HMDSO followed by O2-plasma treatment is a promising method for the adsorption of SVA in dental implant systems.

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