Influence of muscle length on muscle atrophy in the mouse tibialis anterior and soleus muscles

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Author(s)

    • Fujita Naoto
    • Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences
    • Fujimoto Taro
    • Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences
    • Tasaki Hiromitsu
    • Department of Rehabilitation Science, Physical Therapy, Faculty of Human Health, Nagoya Gakuin University
    • Arakawa Takamitsu
    • Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences
    • Matsubara Takako
    • Faculty of Health Sciences, Department of Rehabilitation Physical Therapy Course, Nihon Fukushi University
    • Miki Akinori
    • Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences

Abstract

The tibialis anterior and soleus muscles were fixed at the stretched or shortened positions to examine the influence of muscle length on muscle atrophy. Mice were divided into control (C), hindlimb suspension (HS), hindlimb suspension with ankle joint fixation at the maximum dorsiflexion (HSD), and hindlimb suspension with ankle joint fixation at the maximum plantarflexion (HSP). During the hindlimb suspension, the length of these muscles in the HS and HSP groups was very similar. Fourteen days after the hindlimb suspension, the atrophy of the tibialis anterior muscle in the HS and HSP groups was evidently milder than that in the HSD group, and that in the HS and HSP groups was very similar, suggesting that atrophy of the tibialis anterior muscle might largely depend on muscle length. Atrophy of the soleus muscle in the HSD group was milder than that in the HS and HSP groups, indicating that atrophy of the soleus muscle might also depend on muscle length. But atrophy of this muscle in the HSP group was milder than that in the HS group. These results demonstrate that some factors induced by the joint immobilization might be effective in preventing atrophy of the soleus muscle.

Journal

  • Biomedical Research

    Biomedical Research 30(1), 39-45, 2009

    Biomedical Research Press

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