Inhibition of human renin activity by saponins

• Takahashi Saori

  Akita Research Institute of Food and Brewing

• Hori Kazuyuki

  Akita Research Institute of Food and Brewing

• Hokari Mika

  Akita Research Institute of Food and Brewing

• Gotoh Takeshi

  Department of Engineering in Applied Chemistry, Akita University

• Sugiyama Toshihiro

  Department of Biochemistry, Akita University School of Medicine

Abstract

Renin is the most important enzyme in the renin-angiotensin system. Our previous study led to the identification of soyasaponin I, the first renin inhibitor isolated from soybean. In the present study, the effects of saponins and sapogenols on human renin activities were investigated. Soyasaponins I and II, glycyrrhizin, monoglucuronyl glycyrrhetic acid (MGGA), chikusetsusaponin IV, and Kochia scoparia fruit saponins (momordins) were found to inhibit renin activity. On the other hand, sapogenols (soyasapogenol B and glycyrrhetic acid), saikosaponins b2 and c, and ginsenoside Rb₁ had no effect on renin activity. These results clearly indicate that the 3-O-β-dglucopyranosiduronic moiety in saponins (glucuronide saponin) is essential for renin inhibition.

Journal

• Biomedical Research

  Biomedical Research 31 (2), 155-159, 2010

  Biomedical Research Press

Keywords

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

Details

• CRID: 1390282679878395648
• NII Article ID: 130004903793
• DOI: 10.2220/biomedres.31.155
• ISSN: 1880313X
• ISSN: 03886107
• Web Site: https://search.jamas.or.jp/link/ui/2010293534
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed