Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance

• Kayashima Yasunari

  School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan

• Yamakawa-Kobayashi Kimiko

  School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan

Abstract

Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thioredoxin-dependent peroxidases. We used Drosophila melanogaster to examine the function of Prx3, the Drosophila homolog of human PRDX3. The oxidative stress response in adult Drosophila is age-dependent. RNAiinduced Prx3 knockdown in adult flies did not change their phenotype in normal conditions, but they had a shorter survival than the Prx3⁺ controls in the presence of H₂O₂. The expression levels of the Prx3 were reduced by aging. These results suggest that Prx3 plays an important role in the oxidative stress response and is involved in the age-dependent competence of the oxidative stress response.

Journal

• Biomedical Research

  Biomedical Research 33 (5), 319-322, 2012

  Biomedical Research Press

Keywords

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

Details

• CRID: 1390282679878946944
• NII Article ID: 130004903835
• DOI: 10.2220/biomedres.33.319
• COI: 1:STN:280:DC%2BC3s7gs12mtg%3D%3D
• ISSN: 1880313X
• ISSN: 03886107
• PubMed: 23124252
• Web Site: https://search.jamas.or.jp/link/ui/2013276175
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed