Periosteum-derived cells respond to mechanical stretch and activate Wnt andBMP signaling pathways
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- ITO Ryohei
- Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- MATSUMIYA Tomoh
- Department of VascularBiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- KON Takao
- Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- KUBOTA Kosei
- Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- SAKAKI Hirotaka
- Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- OZAKI Taku
- Department of Ophthalmology,Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- IMAIZUMI Tadaatsu
- Department of VascularBiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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- KIMURA Hiroto
- Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
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抄録
The periosteum supplies osteoblasts and nutrients for bone metabolism and is important for osteoblastdifferentiation and osteogenesis. Recently, periosteum-derived cells have been used for orofacialbone regeneration therapy. However, little is known about the function of the periosteum inphysiological bone remodeling. On our hypothesis that the periosteum senses a mechanical stressto induce bone remodeling, we subjected human jaw bone periosteum cells (HJBPCs) to uniaxialstretching for 24 h and characterized their gene expression profiles by microarray analysis. Of62,976 genes detected, 550 genes related to bone metabolism were extracted, and 76 of thesegenes with large changes in gene expression were short-listed. The results indicated that mechanicalstretch in HJBPCs regulated the expression levels of genes involved in the Wingless-typeMMTV integration (Wnt) site, bone morphogenetic protein (BMP) signaling pathways, and inflammatorycytokines. We propose that periosteum-derived cells sense mechanical stress and thenactivate and regulate signals for osteoblast differentiation and osteogenesis.
収録刊行物
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- Biomedical Research
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Biomedical Research 35 (1), 69-79, 2014
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