Serum expression of S100A6 is a potential detection marker in patients with urothelial carcinoma in the urinary bladder
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- NISHI Morihiro
- Departments of Urology, Kitasato University School of Medicine
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- MATSUMOTO Kazumasa
- Departments of Urology, Kitasato University School of Medicine
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- KOBAYASHI Makoto
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University
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- YANAGITA Kengo
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University
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- MATSUMOTO Toshihide
- Departments of Pathology, Kitasato University School of Medicine
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- NAGASHIO Ryo
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University
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- ISHII Daisuke
- Departments of Urology, Kitasato University School of Medicine
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- FUJITA Tetsuo
- Departments of Urology, Kitasato University School of Medicine
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- SATO Yuichi
- Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University
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- IWAMURA Masatsugu
- Departments of Urology, Kitasato University School of Medicine
書誌事項
- タイトル別名
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- <b>Serum expression of S100A6 is a potential detection marker in patients with urothelial carcinoma in the urinary </b><b>bladder </b>
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抄録
To investigate the level of serum S100A6 in patients with bladder cancer and in healthy controls and compare these levels with clinicopathologic findings, we evaluated the level of serum S100A6 in 30 healthy controls and 50 patients with bladder cancer diagnosed via transurethral resection of bladder tumor and/or radical cystectomy. S100A6 in sera was detected by employing automatic dot blot systems, and the micro Dot Blot array with a 256-solid pin configuration. The normalized signal of serum S100A6 expression in bladder cancer patients was significantly higher than that of healthy controls (P = 0.001). Serum S100A6 expression of non-muscle-invasive cancer (NMIC) was significantly higher than that of healthy controls (P = 0.04). Furthermore, the S100A6 serum level in patients with muscle-invasive bladder cancer was significantly higher than that in patient with NMIC (P = 0.004). The sensitivity and specificity were 48.0% (95% CI: 0.337–0.626) and 93.3% (95% CI: 0.779–0.992), respectively. The area under the curve was 0.727. Serum S100A6 expression is a potentially effective detection marker for bladder cancer. Applying this serum marker to clinical practice would require less-invasive examinations of patients and would help to detect life-threatening cancerous lesions earlier than current modalities.
収録刊行物
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- Biomedical Research
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Biomedical Research 35 (6), 351-356, 2014
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