Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats

この論文にアクセスする

著者

抄録

Propolis, a natural product derived from plants by honeybees, is a mixture of several hundred chemicals, including flavonoids, coumaric acids, and caffeic acids, some of which show estrogen-like activity. In this study, the estrogenic activity of crude ethanolic extract of Brazilian propolis was determined using several <i>in vitro</i> and <i>in vivo</i> assays. Propolis was found to bind to human estrogen receptors (ERs). Furthermore, propolis induced the expression of estrogen-responsive genes in ER-positive MCF-7 and Ishikawa cells. These <i>in vitro</i> assays suggest that propolis exerts estrogenic activity; therefore, <i>in vivo</i> experiments were conducted using ovariectomized rats. Oral administration of propolis (55 or 550 mg/kg/day for 3 days) significantly increased uterine wet weight and luminal epithelium thickness in comparison with the corresponding values in the corn oil-treated control group. Moreover, propolis induced ductal cell proliferation in the mammary glands. These effects were completely inhibited by full ER antagonist ICI 182,780, confirming that the effects of propolis are mediated by the ER. Our data show that oral intake of propolis induces estrogenic activity in ER-expressing organs <i>in vivo</i> and suggest that Brazilian propolis is a useful dietary source of phytoestrogens and a promising treatment for postmenopausal symptoms.

収録刊行物

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 40(2), 235-242, 2015

    一般社団法人 日本毒性学会

各種コード

  • NII論文ID(NAID)
    130004904040
  • NII書誌ID(NCID)
    AN00002808
  • 本文言語コード
    ENG
  • ISSN
    0388-1350
  • NDL 記事登録ID
    026319003
  • NDL 請求記号
    Z19-1022
  • データ提供元
    NDL  J-STAGE 
ページトップへ