Differentiation Therapy for Myelodysplastic Syndrome
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- HINO Ken-ichiro
- Department of Hematology, Showa University, School of Medicine
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- NAKAMAKI Tsuyoshi
- Department of Hematology, Showa University, School of Medicine
Bibliographic Information
- Other Title
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- 分化誘導療法
- ブンカ ユウドウ リョウホウ
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Abstract
The ability of induction of differentiation of leukemia cells was first proved by cultured leukemia cells, and such ability has been also confirmed clinically as a result of observation of the dramatic effect of all-trans retinoic acid on acute promyelocytic leukemia and the usefulness of low-dose of ara-C therapy for acute myeloid leukemia. We studied differentiation induction of primary cultured bone marrow cells from myelodysplastic syndrome (MDS) patients by ara-C and VP16 with or without addition of G-CSF. We also studied clinical efficacy of differentiation therapy in 56 patients with MDS. Differentiation induction effects were observed in 3 of 14 patients treated with G-CSF in combination with low-dose of ara-C or low-dose of VP16. In addition, high-dose methylprednisolone therapy, GM-CSF and anabolic steroid therapy also showed similar effect on refractory anemia, even in a few patients. Since these results suggested the usefulness of differentiation therapy of MDS, it is earnestly hoped that more effective therapy, including a concomitant use of cytokine, might be established as soon as possible.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 34 (3), 283-288, 1993
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680004679424
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- NII Article ID
- 10006595683
- 130004919244
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DyaK3s3ktVKqtA%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 3815893
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- PubMed
- 7683064
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed