Epilepsy and functional brain networks
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- Uehara Taira
- Department of Neurology, Neurological Institute Graduate School of Medical Sciences, Kyushu University
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- Shigeto Hiroshi
- Department of Neurology, Neurological Institute Graduate School of Medical Sciences, Kyushu University
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- Kira Jun-ichi
- Department of Neurology, Neurological Institute Graduate School of Medical Sciences, Kyushu University
Bibliographic Information
- Other Title
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- てんかんと脳機能的ネットワークの関連
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Abstract
Recent resting-state functional MRI (rs-fMRI) studies have demonstrated that the human brain is composed of several essential large-scale functional brain networks, including the “default-mode network”. We analyzed electrocorticogram data from four patients with intractable focal epilepsy and compared the extent of these large-scale functional brain networks with propagation pathways of ictal discharge. We found that large-scale functional brain networks had markedly similar spatial patterns compared with multisite ictal fast activity, suggesting that some epileptic activity propagates along large-scale functional brain networks. Given that decreased functional connectivity in large-scale functional brain networks has been reported in patients with focal epilepsy, ictal propagation may lead to chronic alteration of normal functional networks in the brain.
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 54 (12), 1139-1141, 2014
Societas Neurologica Japonica