ロピナビル/リトナビルが原因と考えられた洞不全症候群の 2 例 [in Japanese] Sick Sinus Syndrome Possibly Due to Lopinavir-ritonavir : Report of Two Cases [in Japanese]
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We describe herein two cases of sick sinus syndrome possibly due to lopinavir-ritonavir in HIV-infected individuals. The heart rate dropped to 30 to 40 beats per minute in both cases, but patients remained asymptomatic and recovered promptly after discontinuation of lopinavir-ritonavir. The time until onset varied ;one patient developed bradyarrhythmia 9 days after the initial dose, and another 4 hours after. Since lopinavir-ritonavir is a frequently used antiretroviral agent, clinicians must be aware of this potentially lethal adverse effect.
- Kansenshogaku Zasshi
Kansenshogaku Zasshi 87(5), 613-617, 2013
The Japanese Association for Infectious Diseases