Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

Access this Article

Search this Article

Author(s)

    • Fukuda Daiju
    • Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Taketani Yoshio
    • Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
    • Iwase Takashi
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Yamada Hirotsugu
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Wakatsuki Tetsuzo
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Shimabukuro Michio
    • Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Sata Masataka
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Yamaguchi Koji
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Niki Toshiyuki
    • Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
    • Uematsu Etsuko
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Bando Sachiko
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Matsuura Tomomi
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Ise Takayuki
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Kusunose Kenya
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Hotchi Junko
    • Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School

Abstract

<b><i>Background:</i></b>Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.<b><i>Methods and Results:</i></b>Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=–0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=–0.56, P<0.01).<b><i>Conclusions:</i></b>miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (<i>Circ J</i> 2015; <b>79:</b> 413–418)

Journal

  • Circulation Journal

    Circulation Journal 79(2), 413-418, 2015

    The Japanese Circulation Society

Codes

  • NII Article ID (NAID)
    130004927043
  • Text Lang
    ENG
  • ISSN
    1346-9843
  • NDL Article ID
    026049097
  • NDL Call No.
    Z54-B860
  • Data Source
    NDL  J-STAGE 
Page Top