Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

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  • Soeki Takeshi
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Yamaguchi Koji
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Niki Toshiyuki
    Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
  • Uematsu Etsuko
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Bando Sachiko
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Matsuura Tomomi
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Ise Takayuki
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Kusunose Kenya
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Hotchi Junko
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Tobiume Takeshi
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Yagi Shusuke
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Fukuda Daiju
    Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Taketani Yoshio
    Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults
  • Iwase Takashi
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Yamada Hirotsugu
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Wakatsuki Tetsuzo
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Shimabukuro Michio
    Department of Cardio-Diabetes Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
  • Sata Masataka
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School

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Background:Although numerous studies have reported altered plasma levels of various microRNAs (miRNAs) in patients with cardiovascular disease, there are no data on the relationship between plasma miRNAs and vulnerable coronary plaque. In this study, we investigated whether plasma miRNAs might be a sensitive marker of coronary plaque vulnerability.Methods and Results:Integrated backscatter intravascular ultrasound (IB-IVUS) was performed in 32 consecutive patients with angina pectoris who underwent percutaneous coronary intervention. Three-dimensional analysis of IB-IVUS was performed to determine the percentage of lipid volume (%LV) and fibrous volume (%FV). Circulating miRNAs were measured in EDTA-plasma simultaneously obtained from the aorta and the coronary sinus (CS). Muscle-enriched (miR-133a, miR-208a, miR-499), vascular-enriched (miR-92a, miR-100, miR-126, miR-127, miR-145), and myeloid cell-enriched miRNAs (miR-155, miR-223) were measured. Plasma miR-100 was higher in the CS than in the aorta, but there were no significant differences in the levels of other miRNAs between the aorta and CS. Plasma miR-100 in the aorta was positively correlated with %LV (r=0.48, P<0.01) and negatively correlated with %FV (r=–0.41, P<0.05). Importantly, transcoronary concentration gradient of circulating miR-100 was more strongly correlated with %LV (r=0.53, P<0.01) and %FV (r=–0.56, P<0.01).Conclusions:miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. (Circ J 2015; 79: 413–418)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (2), 413-418, 2015

    一般社団法人 日本循環器学会

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