Incidence of Ischemic Stroke in Japanese Patients With Atrial Fibrillation Not Receiving Anticoagulation Therapy

• Suzuki Shinya

  Department of Cardiovascular Medicine, The Cardiovascular Institute

• Yamashita Takeshi

  Department of Cardiovascular Medicine, The Cardiovascular Institute

• Okumura Ken

  Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine

• Atarashi Hirotsugu

  Department of Internal Medicine, Nippon Medical School Tama-Nagayama Hospital

• Akao Masaharu

  Department of Cardiology, National Hospital Organization Kyoto Medical Center

• Ogawa Hisashi

  Department of Cardiology, National Hospital Organization Kyoto Medical Center

• Inoue Hiroshi

  Second Department of Internal Medicine, University of Toyama, Graduate School of Medicine

Bibliographic Information

Other Title

• Incidence of Ischemic Stroke in Japanese Patients With Atrial Fibrillation Not Receiving Anticoagulation Therapy : Pooled Analysis of the Shinken Database, J-RHYTHM Registry, and Fushimi AF Registry
• Incidence of ischemic stroke in Japanese patients with atrial fibrillation not receiving anticoagulation therapy—pooled analysis of the Shinken Database, J-RHYTHM Registry, and Fushimi AF Registry.
• – Pooled Analysis of the Shinken Database, J-RHYTHM Registry, and Fushimi AF Registry –

Abstract

Background:The incidence rate of ischemic stroke in Japanese non-valvular atrial fibrillation (NVAF) patients without anticoagulation therapy remains unclear.Methods and Results:We performed a pooled analysis of 3,588 patients from the Shinken Database (n=1,099), J-RHYTHM Registry (n=1,002), and Fushimi AF Registry (n=1,487) to determine the incidence rate of ischemic stroke in Japanese NVAF patients without anticoagulation therapy. Average patient age was 68.1 years. During the follow-up period (total, 5,188 person-years; average, 1.4 years), 69 patients suffered from ischemic stroke (13.3 per 1,000 person-years; 95% confidence intervals [CI]: 10.5–16.8). The incidence rates of ischemic stroke were 5.4, 9.3, and 24.7 per 1,000 person-years and 5.3, 5.5, and 18.4 per 1,000 person-years in patients with low (0), intermediate (1), and high (≥2) CHADS2 and CHA2DS2-VASc scores, respectively. History of ischemic stroke or transient ischemic attack (hazard ratio [HR], 3.25; 95% CI: 1.86–5.67), age ≥75 years (HR, 2.31; 95% CI: 1.18–4.52), and hypertension (HR, 1.69; 95% CI: 1.01–2.86) were independent risk factors for ischemic stroke.Conclusions:A low incidence rate of ischemic stroke was observed in Japanese NVAF patients except for those with CHADS2 score ≥2. In this pooled analysis, history of ischemic stroke or transient ischemic attack, advanced age, and hypertension were identified as independent risk factors for ischemic stroke. (Circ J 2015; 79: 432–438)

Journal

• Circulation Journal

  Circulation Journal 79 (2), 432-438, 2015

  The Japanese Circulation Society

Keywords

• Atrial fibrillation
• Epidemiologic method
• Ischemic stroke
• Prognosis

Details

• CRID: 1390001205108558464
• NII Article ID: 130004927070
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-14-1131
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 026049146
• PubMed: 25501800
• Web Site: http://id.ndl.go.jp/bib/026049146
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026049146
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/2/79_CJ-14-1131/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015295098
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed