A Ribonucleopeptide Receptor Targets Phosphotyrosine

• Hasegawa Tetsuya

  Institute of Advanced Energy, Kyoto University, Japan

• Ohkubo Katsutoshi

  Institute of Advanced Energy, Kyoto University, Japan

• Yoshikawa Susumu

  Institute of Advanced Energy, Kyoto University, Japan

• Morii Takashi

  Institute of Advanced Energy, Kyoto University, Japan

抄録

Tools for selective recognition and sensing of kinase-catalyzed phosphorylation at tyrosine or serine/threonine residues located on the protein surface are essential for understanding signal transduction cascades of living cell. A stable complex of RNA and peptide (ribonucleopeptide) provides a convenient approach to tailor a receptor for small molecules. In vitro selection of an RNA-derived pool of ribonucleopeptide afforded a ribonucleopeptide receptor specific for phosphotyrosine. The phosphotyrosine-binding ribonucleopeptide receptor discriminated phosphotyrosine against tyrosine, phosphoserine and phosphothreonine. [DOI: 10.1380/ejssnt.2005.33]

収録刊行物

• e-Journal of Surface Science and Nanotechnology

  e-Journal of Surface Science and Nanotechnology 3 33-37, 2005

  公益社団法人 日本表面真空学会

キーワード

• Biological aspects of nano-structures
• Self-assembly
• Bio-inspired integrated systems
• Biomedical engineering

詳細情報

• CRID: 1390282680163566720
• NII論文ID: 130004933865
• DOI: 10.1380/ejssnt.2005.33
• ISSN: 13480391
• Web Site: http://www.jstage.jst.go.jp/article/ejssnt/3/0/3_0_33/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可