胎生期の多価不飽和脂肪酸過剰摂取は眼の発生異常を誘発する可能性がある

DOI Web Site 参考文献6件
  • 前川 素子
    理化学研究所 脳科学総合研究センター 分子精神科学研究チーム

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  • Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice
  • タイセイキ ノ タカ フホウワ シボウサン カジョウ セッシュ ワ メ ノ ハッセイ イジョウ オ ユウハツ スル カノウセイ ガ アル

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The eyes are rich in long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic acid (AA; 20:4omega6) and docosahexaenoic acid (DHA; 22:6omega3). Despite their abundance in the eyes, AA and DHA cannot be efficiently synthesized de novo in mammals. During gestation, eye development is exceptionally rapid, and substantial amounts of LC-PUFAs are needed to ensure proper eye development. Here, we studied the influences of dietary LC-PUFAs in dams (C57BL/6 and C3H/He) on the eye morphogenesis and organogenesis of their pups. Intriguingly, fetuses and newborn mice from C57BL/6 dams fed an LC-PUFA (particularly AA)-enriched diet displayed a much higher incidence of eye abnormalities such as microphthalmia (small eye) and corneal opacity than those from dams fed an LC-PUFA-poor diet. The effects of LC-PUFAs on eye anomalies were evident only in the female pups of C57BL/6 inbred mice, not in those of C3H/He mice or male C57BL/6 mice. These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving AA.

収録刊行物

  • 脂質栄養学

    脂質栄養学 21 (1), 59-65, 2012

    日本脂質栄養学会

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