The activity of isolated snail neurons controlling locomotion is affected by glucose

• Dyakonova Varvara

  Laboratory of Comparative Physiology, Institute of Developmental Biology, Russian Academy of Sciences

• Hernádi László

  Balaton Limnological Institute, MTA Centre for Ecological Research

• Ito Etsuro

  Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University

• Dyakonova Taisia

  Laboratory of Comparative Physiology, Institute of Developmental Biology, Russian Academy of Sciences

• Zakharov Igor

  Laboratory of Comparative Physiology, Institute of Developmental Biology, Russian Academy of Sciences

• Sakharov Dmitri

  Laboratory of Comparative Physiology, Institute of Developmental Biology, Russian Academy of Sciences

抄録

The involvement of serotonin in mediating hunger-related changes in behavioral state has been described in many invertebrates. However, the mechanisms by which hunger signals to serotonergic cells remain unknown. We tested the hypothesis that serotonergic neurons can directly sense the concentration of glucose, a metabolic indicator of nutritional state. In the snail Lymnaea stagnalis, we demonstrate that completely isolated pedal serotonergic neurons that control locomotion changed their biophysical characteristics in response to glucose application by lowering membrane potential and decreasing the firing rate. Additionally, the excitatory response of the isolated serotonergic neurons to the neuroactive microenvironment of the pedal ganglia was significantly lowered by glucose application. Because hunger has been reported to increase the activity of select neurons and their responses to the pedal ganglia microenvironment, these responses to glucose are in accordance with the hypothesis that direct glucose signaling is involved in the mediation of the hunger-related behavioral state.

収録刊行物

• BIOPHYSICS

  BIOPHYSICS 11 (0), 55-60, 2015

  日本生物物理学会

キーワード

• behavioral state
• serotonergic neuron
• extrasynaptic release
• volume transmission
• <i>Lymnaea stagnalis</i>

詳細情報

• CRID: 1390001205221627392
• NII論文ID: 130004940813
• DOI: 10.2142/biophysics.11.55
• ISSN: 13492942
• Web Site: https://www.jstage.jst.go.jp/article/biophysics/11/0/11_55/_pdf
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可